Assay Detail
Functional
CHEMBL4263294
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiparasitic activity against Giardia lamblia WB trophozoites assessed as parasite growth inhibition after 48 hrs by ATP bioluminescence-based CellTiter-Glo luminescent cell viability assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Giardia intestinalis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, Synthesis and Preliminary Antimicrobial Evaluation of <i>N</i>-Alkyl Chain Tethered C-5 Functionalized Bis-Isatins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.65 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | 5.19 |
| CHEMBL4277958 | — | — | 1 | 4.74 |
| CHEMBL4278038 | — | — | 1 | 4.62 |
| CHEMBL1760533 | — | — | 1 | 4.61 |
| CHEMBL4288425 | — | — | 1 | 4.58 |
| CHEMBL4289798 | — | — | 1 | 4.54 |
| CHEMBL4288697 | — | — | 1 | 4.50 |
| CHEMBL4284919 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137 | METRONIDAZOLE | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4277958 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL4278038 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL1760533 | — | IC50 | = | 24400.0 | nM | 4.61 |
| CHEMBL4288425 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4289798 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL4288697 | — | IC50 | = | 31500.0 | nM | 4.50 |
| CHEMBL4284919 | — | IC50 | = | 38000.0 | nM | 4.42 |