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Assay Detail

CHEMBL4263546

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial activity against Leishmania donovani MHOM/ET/67/L82 amastigotes after 72 hrs by Alamar Blue assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Intermediate

Target

Leishmania donovani (CHEMBL367)
Type ORGANISM
Organism Leishmania donovani

Publication

Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase.
Chibli LA, Schmidt TJ, Nonato MC, Calil FA, Da Costa FB.
Eur J Med Chem (2018) 157 : 852 -866
PubMed 30145372 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.75 5.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL164 MYRICETIN 1 5.39
CHEMBL487017 APIGETRIN 1 5.31
CHEMBL309490 GALANGIN 1 5.26
CHEMBL150 KAEMPFEROL 1.0 1 4.99
CHEMBL4278464 1 4.56
CHEMBL145 CAFFEIC ACID 3.0 1 4.51
CHEMBL52564 O-COUMARIC ACID 1 4.44
CHEMBL27246 CINNAMIC ACID 1 4.42
CHEMBL226335 RUTIN 3.0 1 4.31
CHEMBL226034 TAMARIXETIN 1 4.27
CHEMBL51628 UMBELLIFERONE 1 -
CHEMBL311498 CIANIDANOL 4.0 1 -
CHEMBL32749 FERULATE -1.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL164 MYRICETIN IC50 = 4080.0 nM 5.39
CHEMBL487017 APIGETRIN IC50 = 4860.0 nM 5.31
CHEMBL309490 GALANGIN IC50 = 5550.0 nM 5.26
CHEMBL150 KAEMPFEROL IC50 = 10140.0 nM 4.99
CHEMBL4278464 IC50 = 27800.0 nM 4.56
CHEMBL145 CAFFEIC ACID IC50 = 31100.0 nM 4.51
CHEMBL52564 O-COUMARIC ACID IC50 = 36550.0 nM 4.44
CHEMBL27246 CINNAMIC ACID IC50 = 37820.0 nM 4.42
CHEMBL226335 RUTIN IC50 = 49140.0 nM 4.31
CHEMBL226034 TAMARIXETIN IC50 = 53150.0 nM 4.27
CHEMBL51628 UMBELLIFERONE IC50 = 172070.0 nM -
CHEMBL311498 CIANIDANOL IC50 = 103350.0 nM -
CHEMBL32749 FERULATE IC50 = 154590.0 nM -