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Assay Detail

CHEMBL4263720

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured at 1 min intervals for 30 mins by Ellman's method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Electrophorus electricus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL4078)
Type SINGLE PROTEIN
Organism Electrophorus electricus

Publication

Unexpected AChE inhibitory activity of (2E)α,β-unsaturated fatty acids.
Loesche A, Wiemann J, Al Halabi Z, Karasch J, Sippl W, Csuk R.
Bioorg Med Chem Lett (2018) 28 : 3315 -3319
PubMed 30220607 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 5.20 5.91

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1555 GALANTAMINE HYDROBROMIDE 4.0 1 5.91
CHEMBL4292703 1 5.37
CHEMBL4282100 1 5.30
CHEMBL46403 STEARIC ACID -1.0 1 5.12
CHEMBL4285532 1 5.10
CHEMBL82293 PALMITIC ACID -1.0 1 4.99
CHEMBL4284416 1 4.93
CHEMBL1173381 ARACHIDIC ACID 1 4.89
CHEMBL1173474 BEHENIC ACID 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1555 GALANTAMINE HYDROBROMIDE IC50 = 1230.0 nM 5.91
CHEMBL4292703 IC50 = 4300.0 nM 5.37
CHEMBL4282100 IC50 = 5000.0 nM 5.30
CHEMBL46403 STEARIC ACID IC50 = 7500.0 nM 5.12
CHEMBL4285532 IC50 = 7900.0 nM 5.10
CHEMBL82293 PALMITIC ACID IC50 = 10150.0 nM 4.99
CHEMBL4284416 IC50 = 11720.0 nM 4.93
CHEMBL1173381 ARACHIDIC ACID IC50 = 12800.0 nM 4.89
CHEMBL1173474 BEHENIC ACID IC50 - -