Assay Detail
Functional
CHEMBL4264651
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Antiproliferative activity in human CEM cells after 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Tri-armed ligands of G-quadruplex on heteroarene-fused anthraquinone scaffolds: Design, synthesis and pre-screening of biological properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.02 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.00 |
| CHEMBL472033 | — | — | 1 | 4.96 |
| CHEMBL4282825 | — | — | 1 | 4.96 |
| CHEMBL4288802 | — | — | 1 | 4.96 |
| CHEMBL4291113 | — | — | 1 | 4.92 |
| CHEMBL4290713 | — | — | 1 | 4.92 |
| CHEMBL4280487 | — | — | 1 | 4.89 |
| CHEMBL4294050 | — | — | 1 | 4.82 |
| CHEMBL4283938 | — | — | 1 | 4.80 |
| CHEMBL4284882 | — | — | 1 | 4.80 |
| CHEMBL4293076 | — | — | 1 | 4.77 |
| CHEMBL4283475 | — | — | 1 | 4.75 |
| CHEMBL4283533 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL472033 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4282825 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4288802 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4291113 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4290713 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4280487 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4294050 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4283938 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4284882 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4293076 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4283475 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4283533 | — | IC50 | = | 21000.0 | nM | 4.68 |