Assay Detail
Functional
CHEMBL4264674
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Antiproliferative activity against human A375 cells after 72 hrs by CCK8 assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis and biological evaluation of novel carbamodithioates as anti-proliferative agents against human cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.77 | 4.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285834 | — | — | 1 | 4.88 |
| CHEMBL4277904 | — | — | 1 | 4.86 |
| CHEMBL4279277 | — | — | 1 | 4.86 |
| CHEMBL4286592 | — | — | 1 | 4.80 |
| CHEMBL4278671 | — | — | 1 | 4.79 |
| CHEMBL4282429 | — | — | 1 | 4.78 |
| CHEMBL4294984 | — | — | 1 | 4.78 |
| CHEMBL4294424 | — | — | 1 | 4.78 |
| CHEMBL4293808 | — | — | 1 | 4.77 |
| CHEMBL49659 | — | — | 1 | 4.73 |
| CHEMBL4287198 | — | — | 1 | 4.71 |
| CHEMBL4285734 | — | — | 1 | 4.70 |
| CHEMBL4283228 | — | — | 1 | 4.70 |
| CHEMBL48802 | SULFORAPHANE | 3.0 | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285834 | — | IC50 | = | 13180.0 | nM | 4.88 |
| CHEMBL4277904 | — | IC50 | = | 13840.0 | nM | 4.86 |
| CHEMBL4279277 | — | IC50 | = | 13960.0 | nM | 4.86 |
| CHEMBL4286592 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL4278671 | — | IC50 | = | 16250.0 | nM | 4.79 |
| CHEMBL4282429 | — | IC50 | = | 16450.0 | nM | 4.78 |
| CHEMBL4294984 | — | IC50 | = | 16660.0 | nM | 4.78 |
| CHEMBL4294424 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL4293808 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL49659 | — | IC50 | = | 18740.0 | nM | 4.73 |
| CHEMBL4287198 | — | IC50 | = | 19450.0 | nM | 4.71 |
| CHEMBL4285734 | — | IC50 | = | 19890.0 | nM | 4.70 |
| CHEMBL4283228 | — | IC50 | = | 19770.0 | nM | 4.70 |
| CHEMBL48802 | SULFORAPHANE | IC50 | = | 24520.0 | nM | 4.61 |