Assay Detail
Binding
CHEMBL4265142
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Vibrio cholerae sialidase using Neu5Acalpha2-3GalbetapNP as substrate after 30 mins by colorimetric assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Vibrio cholerae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Sialidase (CHEMBL1075100) ↗| Type | SINGLE PROTEIN |
| Organism | Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) |
Publication
Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.83 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96712 | NEU5AC2EN | — | 1 | 5.07 |
| CHEMBL4289476 | — | — | 1 | 4.96 |
| CHEMBL4282280 | — | — | 1 | 4.87 |
| CHEMBL1289311 | — | — | 1 | 4.70 |
| CHEMBL4278803 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96712 | NEU5AC2EN | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4289476 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL4282280 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL1289311 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4278803 | — | IC50 | = | 28900.0 | nM | 4.54 |