Assay Detail
Binding
CHEMBL4265149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Mycobacterium tuberculosis PtpA using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition and measured every minute for 10 mins by UV-VIS spectrophotometric analysis
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Low molecular weight protein-tyrosine phosphatase A (CHEMBL4542) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Synthetic thiosemicarbazones as a new class of Mycobacterium tuberculosis protein tyrosine phosphatase A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 4.95 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4288744 | — | — | 1 | 5.54 |
| CHEMBL4280516 | — | — | 1 | 5.13 |
| CHEMBL4282817 | — | — | 1 | 5.04 |
| CHEMBL4292242 | — | — | 1 | 5.02 |
| CHEMBL4279400 | — | — | 1 | 4.87 |
| CHEMBL4294511 | — | — | 1 | 4.82 |
| CHEMBL4280931 | — | — | 1 | 4.75 |
| CHEMBL4285399 | — | — | 1 | 4.74 |
| CHEMBL4287324 | — | — | 1 | 4.62 |
| CHEMBL4288647 | — | — | 1 | - |
| CHEMBL1939444 | — | — | 1 | - |
| CHEMBL4285306 | — | — | 1 | - |
| CHEMBL4293122 | — | — | 1 | - |
| CHEMBL4281873 | — | — | 1 | - |
| CHEMBL4289736 | — | — | 1 | - |
| CHEMBL4278411 | — | — | 1 | - |
| CHEMBL4286321 | — | — | 1 | - |
| CHEMBL4281971 | — | — | 1 | - |
| CHEMBL4291145 | — | — | 1 | - |
| CHEMBL4277049 | — | — | 1 | - |
| CHEMBL4291222 | — | — | 1 | - |
| CHEMBL4285955 | — | — | 1 | - |
| CHEMBL4287446 | — | — | 1 | - |
| CHEMBL4290703 | — | — | 1 | - |
| CHEMBL4279362 | — | — | 1 | - |
| CHEMBL4287292 | — | — | 1 | - |
| CHEMBL4283929 | — | — | 1 | - |
| CHEMBL4291102 | — | — | 1 | - |
| CHEMBL4276795 | — | — | 1 | - |
| CHEMBL4280478 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4288744 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4280516 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4282817 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4292242 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4279400 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL4294511 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL4280931 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL4285399 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL4287324 | — | IC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL4278506 | — | IC50 | - | — | - | |
| CHEMBL4289164 | — | IC50 | - | — | - | |
| CHEMBL4280855 | — | IC50 | - | — | - | |
| CHEMBL4277444 | — | IC50 | - | — | - | |
| CHEMBL4287737 | — | IC50 | - | — | - | |
| CHEMBL4294110 | — | IC50 | - | — | - | |
| CHEMBL4284336 | — | IC50 | - | — | - | |
| CHEMBL4288832 | — | IC50 | - | — | - | |
| CHEMBL4287031 | — | IC50 | - | — | - | |
| CHEMBL4291145 | — | IC50 | - | — | - | |
| CHEMBL4292578 | — | IC50 | - | — | - | |
| CHEMBL4279102 | — | IC50 | - | — | - | |
| CHEMBL4291075 | — | IC50 | - | — | - | |
| CHEMBL4280445 | — | IC50 | - | — | - | |
| CHEMBL4290444 | — | IC50 | - | — | - | |
| CHEMBL4282571 | — | IC50 | - | — | - | |
| CHEMBL4293848 | — | IC50 | - | — | - | |
| CHEMBL4277091 | — | IC50 | - | — | - | |
| CHEMBL1939442 | — | IC50 | - | — | - | |
| CHEMBL4294257 | — | IC50 | - | — | - | |
| CHEMBL4291222 | — | IC50 | - | — | - | |
| CHEMBL4280478 | — | IC50 | - | — | - | |
| CHEMBL4276795 | — | IC50 | - | — | - | |
| CHEMBL4291102 | — | IC50 | - | — | - | |
| CHEMBL4283929 | — | IC50 | - | — | - | |
| CHEMBL4287292 | — | IC50 | - | — | - | |
| CHEMBL4279362 | — | IC50 | - | — | - | |
| CHEMBL4290703 | — | IC50 | - | — | - | |
| CHEMBL4287446 | — | IC50 | - | — | - | |
| CHEMBL4285955 | — | IC50 | - | — | - | |
| CHEMBL4281971 | — | IC50 | - | — | - | |
| CHEMBL4277049 | — | IC50 | - | — | - | |
| CHEMBL4288647 | — | IC50 | - | — | - | |
| CHEMBL1939444 | — | IC50 | - | — | - | |
| CHEMBL4285306 | — | IC50 | - | — | - | |
| CHEMBL4293122 | — | IC50 | - | — | - | |
| CHEMBL4281873 | — | IC50 | - | — | - | |
| CHEMBL4289736 | — | IC50 | - | — | - | |
| CHEMBL4278411 | — | IC50 | - | — | - | |
| CHEMBL4286321 | — | IC50 | - | — | - |