Assay Detail
Binding
CHEMBL4265153
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PTP-PEST using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition and measured every minute for 10 mins by UV-VIS spectrophotometric analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 12 (CHEMBL3236) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthetic thiosemicarbazones as a new class of Mycobacterium tuberculosis protein tyrosine phosphatase A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.80 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4288744 | — | — | 1 | 4.80 |
| CHEMBL4292242 | — | — | 1 | - |
| CHEMBL4280516 | — | — | 1 | - |
| CHEMBL4282817 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4288744 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL4292242 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4280516 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4282817 | — | IC50 | > | 50000.0 | nM | - |