Assay Detail
Binding
CHEMBL4265160
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Non-competitive inhibition of Mycobacterium tuberculosis PtpA using p-nitrophenyl phosphate as substrate by Michaelis-Menten plot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Low molecular weight protein-tyrosine phosphatase A (CHEMBL4542) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Synthetic thiosemicarbazones as a new class of Mycobacterium tuberculosis protein tyrosine phosphatase A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.65 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4292242 | — | — | 1 | 5.92 |
| CHEMBL4288744 | — | — | 1 | 5.77 |
| CHEMBL4280516 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4292242 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL4288744 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL4280516 | — | Ki | = | 5600.0 | nM | 5.25 |