Assay Detail
Functional
CHEMBL4265358
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Antiproliferative activity against human U87MG cells after 72 hrs by MTS assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an α7-nAChR, α9-nAChR Antagonist and of a Pro-Oxidant Mitocan.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.24 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4280206 | — | — | 1 | 7.22 |
| CHEMBL4281312 | — | — | 1 | 7.16 |
| CHEMBL4290427 | — | — | 1 | 7.05 |
| CHEMBL4285772 | — | — | 1 | 6.96 |
| CHEMBL4291927 | — | — | 1 | 6.44 |
| CHEMBL4277852 | — | — | 1 | 6.42 |
| CHEMBL4280452 | — | — | 1 | 6.24 |
| CHEMBL4284717 | — | — | 1 | 6.19 |
| CHEMBL4288506 | — | — | 1 | 6.17 |
| CHEMBL4276776 | — | — | 1 | 6.07 |
| CHEMBL4288118 | — | — | 1 | 5.85 |
| CHEMBL4291079 | — | — | 1 | 5.75 |
| CHEMBL4293646 | — | — | 1 | 5.41 |
| CHEMBL1257065 | STILONIUM IODIDE | 2.0 | 1 | 5.36 |
| CHEMBL4287656 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4280206 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4281312 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4290427 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4285772 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4291927 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4277852 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4280452 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4284717 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4288506 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4276776 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4288118 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4291079 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4293646 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1257065 | STILONIUM IODIDE | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4287656 | — | IC50 | = | 5300.0 | nM | 5.28 |