Assay Detail
ADMET
CHEMBL4265361
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Cytotoxicity against mouse astrocytes assessed as reduction in cell viability after 72 hrs by MTS assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | Astrocyte |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an α7-nAChR, α9-nAChR Antagonist and of a Pro-Oxidant Mitocan.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.32 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4284717 | — | — | 1 | 6.40 |
| CHEMBL4280206 | — | — | 1 | 6.22 |
| CHEMBL4276776 | — | — | 1 | 6.00 |
| CHEMBL4285772 | — | — | 1 | 5.70 |
| CHEMBL4293646 | — | — | 1 | 5.24 |
| CHEMBL4291079 | — | — | 1 | 4.70 |
| CHEMBL4280452 | — | — | 1 | 4.66 |
| CHEMBL4287656 | — | — | 1 | 4.64 |
| CHEMBL1257065 | STILONIUM IODIDE | 2.0 | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4284717 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4280206 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4276776 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4285772 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4293646 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4291079 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4280452 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4287656 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1257065 | STILONIUM IODIDE | IC50 | = | 47000.0 | nM | 4.33 |