Assay Detail
Binding
CHEMBL4265579
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Inhibition of JAK3 in human whole blood assessed as reduction in IL15-induced STAT5 phosphorylation preincubated for 75 mins followed by IL15 addition and measured after 15 mins by FACS analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.47 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4288086 | — | — | 1 | 6.02 |
| CHEMBL4279720 | — | — | 1 | 5.26 |
| CHEMBL4284396 | — | — | 1 | 5.14 |
| CHEMBL4281393 | — | — | 1 | - |
| CHEMBL4294868 | — | — | 1 | - |
| CHEMBL4292320 | — | — | 1 | - |
| CHEMBL4285555 | — | — | 1 | - |
| CHEMBL4277610 | — | — | 1 | - |
| CHEMBL4277193 | — | — | 1 | - |
| CHEMBL4287845 | — | — | 1 | - |
| CHEMBL4292341 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4288086 | — | IC50 | = | 953.0 | nM | 6.02 |
| CHEMBL4279720 | — | IC50 | = | 5480.0 | nM | 5.26 |
| CHEMBL4284396 | — | IC50 | = | 7252.0 | nM | 5.14 |
| CHEMBL4281393 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4294868 | — | IC50 | - | — | - | |
| CHEMBL4292320 | — | IC50 | - | — | - | |
| CHEMBL4285555 | — | IC50 | - | — | - | |
| CHEMBL4277610 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4277193 | — | IC50 | - | — | - | |
| CHEMBL4287845 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4292341 | — | IC50 | > | 10000.0 | nM | - |