Assay Detail
Functional
CHEMBL4265688
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Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and in vitro antitumor activity of novel alkenyl derivatives of pyridoxine, bioisosteric analogs of feruloyl methane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.38 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.40 |
| CHEMBL4295033 | — | — | 1 | 5.55 |
| CHEMBL4292030 | — | — | 1 | 5.39 |
| CHEMBL106509 | DEHYDROZINGERONE | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4295033 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4292030 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL106509 | DEHYDROZINGERONE | IC50 | = | 70000.0 | nM | 4.16 |