Assay Detail
Binding
CHEMBL4266274
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Inhibition of Aurora A kinase (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A comprehensive review on Aurora kinase: Small molecule inhibitors and clinical trial studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.97 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 9.22 |
| CHEMBL483158 | ALISERTIB | 3.0 | 1 | 8.92 |
| CHEMBL502124 | — | — | 1 | 8.47 |
| CHEMBL259084 | MLN-8054 | 1.0 | 1 | 8.40 |
| CHEMBL2140408 | AMG-900 | 1.0 | 1 | 8.30 |
| CHEMBL4277690 | — | — | 1 | 8.05 |
| CHEMBL402548 | DANUSERTIB | 2.0 | 1 | 7.89 |
| CHEMBL482968 | ENMD-2076 | 2.0 | 1 | 7.85 |
| CHEMBL383899 | ANILINOPYRIMIDINE1 | — | 1 | 7.38 |
| CHEMBL202721 | — | — | 1 | 6.96 |
| CHEMBL272125 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL572878 | TOZASERTIB | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL483158 | ALISERTIB | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL502124 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL259084 | MLN-8054 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2140408 | AMG-900 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4277690 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL402548 | DANUSERTIB | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL482968 | ENMD-2076 | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL383899 | ANILINOPYRIMIDINE1 | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL202721 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL272125 | — | IC50 | = | 560.0 | nM | 6.25 |