Assay Detail
Binding
CHEMBL4266276
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant aurora B (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A comprehensive review on Aurora kinase: Small molecule inhibitors and clinical trial studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.67 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215152 | DEFOSBARASERTIB | 2.0 | 1 | 9.43 |
| CHEMBL1090479 | GSK-1070916 | 1.0 | 1 | 8.46 |
| CHEMBL2140408 | AMG-900 | 1.0 | 1 | 8.40 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 7.75 |
| CHEMBL4277690 | — | — | 1 | 7.51 |
| CHEMBL4282530 | — | — | 1 | 7.39 |
| CHEMBL274654 | ORANTINIB | 3.0 | 1 | 7.33 |
| CHEMBL402548 | DANUSERTIB | 2.0 | 1 | 7.10 |
| CHEMBL202721 | — | — | 1 | 6.89 |
| CHEMBL483158 | ALISERTIB | 3.0 | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215152 | DEFOSBARASERTIB | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL1090479 | GSK-1070916 | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL2140408 | AMG-900 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4277690 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4282530 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL274654 | ORANTINIB | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL402548 | DANUSERTIB | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL202721 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL483158 | ALISERTIB | IC50 | = | 396.5 | nM | 6.40 |