Assay Detail
Functional
CHEMBL4267042
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Antimalarial activity against Plasmodium falciparum after 48 hrs by microbeta scintillation counting-based [3H]-hypoxanthine incorporation assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 6.52 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285682 | — | — | 1 | 7.60 |
| CHEMBL4288816 | — | — | 1 | 7.14 |
| CHEMBL4294776 | — | — | 1 | 7.05 |
| CHEMBL4288103 | — | — | 1 | 7.04 |
| CHEMBL4286880 | — | — | 1 | 6.98 |
| CHEMBL4286841 | — | — | 1 | 6.95 |
| CHEMBL4283774 | — | — | 1 | 6.84 |
| CHEMBL4279865 | — | — | 1 | 6.81 |
| CHEMBL425949 | — | — | 1 | 6.40 |
| CHEMBL190228 | — | — | 1 | 6.35 |
| CHEMBL4284547 | — | — | 1 | 5.88 |
| CHEMBL4282026 | — | — | 1 | 5.83 |
| CHEMBL4287934 | — | — | 1 | 5.81 |
| CHEMBL4281827 | — | — | 1 | 5.74 |
| CHEMBL4280027 | — | — | 1 | 5.34 |
| CHEMBL4291946 | — | — | 1 | - |
| CHEMBL4295199 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285682 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4288816 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4294776 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4288103 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4286880 | — | EC50 | = | 105.0 | nM | 6.98 |
| CHEMBL4286841 | — | EC50 | = | 113.0 | nM | 6.95 |
| CHEMBL4283774 | — | EC50 | = | 144.0 | nM | 6.84 |
| CHEMBL4279865 | — | EC50 | = | 155.0 | nM | 6.81 |
| CHEMBL425949 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL190228 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4284547 | — | EC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL4282026 | — | EC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL4287934 | — | EC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4281827 | — | EC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL4280027 | — | EC50 | = | 4570.0 | nM | 5.34 |
| CHEMBL4291946 | — | EC50 | - | — | - | |
| CHEMBL4295199 | — | EC50 | - | — | - |