Compound Detail
CHEMBL4279865
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CN1CCC(c2nc(-c3ccc(F)cc3)c(-c3ccnc(Nc4ccc(N5CCN(C)CC5)cc4)n3)s2)CC1
Basic Information
| ChEMBL ID | CHEMBL4279865 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZTMGKGCJGHBZPP-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
543.7
MW (Da)
5.71
ALogP
8
HBA
1
HBD
60.4
PSA (Ų)
0.33
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.81
IC50 1 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-dependent protein kinase CHEMBL2169724 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
| Plasmodium falciparum CHEMBL364 | EC50 | 6.81 | 6.81 | 155.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-dependent protein kinase | IC50 | = | 1.0 | nM | 9.0 | Inhibition of Plasmodium falciparum protein kinase G | 30174152 |
| Plasmodium falciparum | EC50 | = | 155.0 | nM | 6.81 | Antimalarial activity against Plasmodium falciparum after 48 hrs by microbeta sc... | 30174152 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30174152 | 10.1016/j.bmcl.2018.08.028 | Plasmodium falciparum | 1 |
| 30174152 | 10.1016/j.bmcl.2018.08.028 | cGMP-dependent protein kinase | 1 |
Data from ChEMBL 36 via Core Engine