Assay Detail
Binding
CHEMBL4267041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium falciparum protein kinase G
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-dependent protein kinase (CHEMBL2169724) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.29 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285682 | — | — | 1 | 9.52 |
| CHEMBL4288816 | — | — | 1 | 9.30 |
| CHEMBL4288103 | — | — | 1 | 9.15 |
| CHEMBL4286880 | — | — | 1 | 9.05 |
| CHEMBL4279865 | — | — | 1 | 9.00 |
| CHEMBL4286841 | — | — | 1 | 8.70 |
| CHEMBL425949 | — | — | 1 | 8.52 |
| CHEMBL4284547 | — | — | 1 | 8.22 |
| CHEMBL190228 | — | — | 1 | 8.22 |
| CHEMBL4283774 | — | — | 1 | 8.22 |
| CHEMBL4287934 | — | — | 1 | 8.05 |
| CHEMBL4282026 | — | — | 1 | 7.82 |
| CHEMBL4281827 | — | — | 1 | 7.77 |
| CHEMBL4295199 | — | — | 1 | 7.77 |
| CHEMBL4280027 | — | — | 1 | 7.48 |
| CHEMBL4294776 | — | — | 1 | 7.33 |
| CHEMBL4291946 | — | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285682 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4288816 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4288103 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4286880 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4279865 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4286841 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL425949 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4284547 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL190228 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4283774 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4287934 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4282026 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4281827 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4295199 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4280027 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4294776 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4291946 | — | IC50 | = | 149.0 | nM | 6.83 |