Assay Detail
Functional
CHEMBL4268103
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Human immunodeficiency virus 1 NL4-3 infected in human MT4 cells assessed as protection against virus-induced cytopathic effect after 2 days by bright-glo luciferase reporter gene assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 5.09 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4278296 | — | — | 1 | 5.36 |
| CHEMBL1229713 | — | — | 1 | 5.22 |
| CHEMBL4279975 | — | — | 1 | 5.18 |
| CHEMBL4283445 | — | — | 1 | 5.16 |
| CHEMBL4282046 | — | — | 1 | 5.10 |
| CHEMBL4294928 | — | — | 1 | 5.05 |
| CHEMBL4294506 | — | — | 1 | 5.04 |
| CHEMBL4284291 | — | — | 1 | 4.99 |
| CHEMBL4290211 | — | — | 1 | 4.98 |
| CHEMBL4291292 | — | — | 1 | 4.83 |
| CHEMBL4289920 | — | — | 1 | - |
| CHEMBL4287331 | — | — | 1 | - |
| CHEMBL4276685 | — | — | 1 | - |
| CHEMBL4283245 | — | — | 1 | - |
| CHEMBL4291099 | — | — | 1 | - |
| CHEMBL4286604 | — | — | 1 | - |
| CHEMBL4287679 | — | — | 1 | - |
| CHEMBL4286201 | — | — | 1 | - |
| CHEMBL4287882 | — | — | 1 | - |
| CHEMBL4279546 | — | — | 1 | - |
| CHEMBL4279776 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4278296 | — | EC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL1229713 | — | EC50 | = | 5950.0 | nM | 5.22 |
| CHEMBL4279975 | — | EC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL4283445 | — | EC50 | = | 6910.0 | nM | 5.16 |
| CHEMBL4282046 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4294928 | — | EC50 | = | 8980.0 | nM | 5.05 |
| CHEMBL4294506 | — | EC50 | = | 9110.0 | nM | 5.04 |
| CHEMBL4284291 | — | EC50 | = | 10160.0 | nM | 4.99 |
| CHEMBL4290211 | — | EC50 | = | 10450.0 | nM | 4.98 |
| CHEMBL4291292 | — | EC50 | = | 14930.0 | nM | 4.83 |
| CHEMBL4289920 | — | EC50 | - | — | - | |
| CHEMBL4287331 | — | EC50 | - | — | - | |
| CHEMBL4276685 | — | EC50 | > | 19840.0 | nM | - |
| CHEMBL4283245 | — | EC50 | - | — | - | |
| CHEMBL4291099 | — | EC50 | > | 19840.0 | nM | - |
| CHEMBL4286604 | — | EC50 | > | 21530.0 | nM | - |
| CHEMBL4287679 | — | EC50 | > | 19430.0 | nM | - |
| CHEMBL4286201 | — | EC50 | > | 19250.0 | nM | - |
| CHEMBL4287882 | — | EC50 | - | — | - | |
| CHEMBL4279546 | — | EC50 | - | — | - | |
| CHEMBL4279776 | — | EC50 | - | — | - |