Assay Detail
Functional
CHEMBL4268109
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against ENV pseudotyped HIV1 B41 infected in human U87 cells expressing CD4/CCR5 measured after 48 hrs by luciferase reporter gene assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | U87 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.08 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229713 | — | — | 1 | 7.00 |
| CHEMBL4278296 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229713 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4278296 | — | IC50 | = | 7000.0 | nM | 5.16 |