Assay Detail
Functional
CHEMBL4268233
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Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.72 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4278951 | — | — | 1 | 6.72 |
| CHEMBL4294153 | — | — | 1 | 6.18 |
| CHEMBL4294092 | — | — | 1 | 6.11 |
| CHEMBL4280540 | — | — | 1 | 6.10 |
| CHEMBL4280050 | — | — | 1 | 6.04 |
| CHEMBL4292408 | — | — | 1 | 6.00 |
| CHEMBL4283921 | — | — | 1 | 6.00 |
| CHEMBL4289006 | — | — | 1 | 5.98 |
| CHEMBL4286867 | — | — | 1 | 5.98 |
| CHEMBL4285223 | — | — | 1 | 5.97 |
| CHEMBL4282456 | — | — | 1 | 5.94 |
| CHEMBL4290748 | — | — | 1 | 5.94 |
| CHEMBL4295224 | — | — | 1 | 5.92 |
| CHEMBL4278591 | — | — | 1 | 5.82 |
| CHEMBL4283513 | — | — | 1 | 5.77 |
| CHEMBL4291781 | — | — | 1 | 5.75 |
| CHEMBL4290831 | — | — | 1 | 5.71 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.66 |
| CHEMBL3917405 | — | — | 1 | 5.65 |
| CHEMBL4095596 | — | — | 1 | 5.63 |
| CHEMBL4281785 | — | — | 1 | 5.60 |
| CHEMBL4294155 | — | — | 1 | 5.13 |
| CHEMBL4290689 | — | — | 1 | 4.74 |
| CHEMBL4284388 | — | — | 1 | 4.47 |
| CHEMBL4282471 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4278951 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4294153 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4294092 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4280540 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4280050 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4292408 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4283921 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4289006 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4286867 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4285223 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL4282456 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4290748 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4295224 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL4278591 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL4283513 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL4291781 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4290831 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3917405 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL4095596 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL4281785 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL4294155 | — | IC50 | = | 7340.0 | nM | 5.13 |
| CHEMBL4290689 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL4284388 | — | IC50 | = | 34100.0 | nM | 4.47 |
| CHEMBL4282471 | — | IC50 | = | 65600.0 | nM | 4.18 |