Assay Detail
Functional
CHEMBL4268852
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.76 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4293461 | — | — | 1 | 6.70 |
| CHEMBL4278654 | — | — | 1 | 5.90 |
| CHEMBL4282023 | — | — | 1 | 5.80 |
| CHEMBL4288385 | — | — | 1 | 5.76 |
| CHEMBL4289029 | — | — | 1 | 5.70 |
| CHEMBL4277703 | — | — | 1 | 5.70 |
| CHEMBL4290932 | — | — | 1 | 5.70 |
| CHEMBL4283071 | — | — | 1 | 5.70 |
| CHEMBL4288566 | — | — | 1 | 5.70 |
| CHEMBL4277916 | — | — | 1 | 5.70 |
| CHEMBL4281599 | — | — | 1 | 5.70 |
| CHEMBL3560171 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4293461 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4278654 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL4282023 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL4288385 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4289029 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4277703 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4290932 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4283071 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4288566 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4277916 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4281599 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3560171 | — | IC50 | = | 7900.0 | nM | 5.10 |