Assay Detail
Functional
CHEMBL4269112
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Cytotoxicity against mouse FL5.12 cells after 48 hrs by DAPI or propidium iodide staining-based flow cytometric analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | FL5.12 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.18 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4279731 | — | — | 1 | 5.75 |
| CHEMBL4292765 | — | — | 1 | 5.70 |
| CHEMBL4281431 | — | — | 1 | 5.68 |
| CHEMBL4291694 | — | — | 1 | 5.68 |
| CHEMBL4284894 | — | — | 1 | 5.68 |
| CHEMBL314854 | FINGOLIMOD | 4.0 | 1 | 5.68 |
| CHEMBL4281064 | — | — | 1 | 5.66 |
| CHEMBL4280342 | — | — | 1 | 5.60 |
| CHEMBL4291660 | — | — | 1 | 5.55 |
| CHEMBL4283800 | — | — | 1 | 5.52 |
| CHEMBL4287635 | — | — | 1 | 5.52 |
| CHEMBL4288280 | — | — | 1 | 5.40 |
| CHEMBL4276918 | — | — | 1 | 5.08 |
| CHEMBL4284845 | — | — | 1 | 4.99 |
| CHEMBL4292055 | — | — | 1 | 4.96 |
| CHEMBL4277643 | — | — | 1 | 4.91 |
| CHEMBL4294878 | — | — | 1 | 4.89 |
| CHEMBL4284248 | — | — | 1 | 4.89 |
| CHEMBL4279964 | — | — | 1 | 4.82 |
| CHEMBL4288242 | — | — | 1 | 4.82 |
| CHEMBL4283206 | — | — | 1 | 4.77 |
| CHEMBL4291060 | — | — | 1 | 4.73 |
| CHEMBL4287873 | — | — | 1 | 4.71 |
| CHEMBL4280828 | — | — | 1 | 4.60 |
| CHEMBL4291467 | — | — | 1 | 4.60 |
| CHEMBL4284474 | — | — | 1 | 4.55 |
| CHEMBL4295124 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4279731 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4292765 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4281431 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4291694 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4284894 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL314854 | FINGOLIMOD | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4281064 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4280342 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4291660 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4283800 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4287635 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4288280 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4276918 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4284845 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL4292055 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL4277643 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4294878 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL4284248 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL4279964 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL4288242 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL4283206 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4291060 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL4287873 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL4280828 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4291467 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL4284474 | — | IC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL4295124 | — | IC50 | > | 40000.0 | nM | - |