Assay Detail
Binding
CHEMBL4269175
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human IAP expressed in African green monkey COS7 cell membranes using CDP-star as substrate pretreated for 5 to 10 mins followed by substrate addition and measured after 15 to 20 mins by spectrophotometric method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Intestinal-type alkaline phosphatase (CHEMBL5573) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.41 | 5.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4283809 | — | — | 1 | 5.98 |
| CHEMBL4289564 | — | — | 1 | 5.92 |
| CHEMBL4294381 | — | — | 1 | 5.91 |
| CHEMBL4290987 | — | — | 1 | 5.82 |
| CHEMBL4287165 | — | — | 1 | 5.75 |
| CHEMBL4287568 | — | — | 1 | 5.59 |
| CHEMBL4287104 | — | — | 1 | 5.51 |
| CHEMBL4280545 | — | — | 1 | 5.43 |
| CHEMBL4276925 | — | — | 1 | 5.43 |
| CHEMBL4292898 | — | — | 1 | 5.42 |
| CHEMBL4282304 | — | — | 1 | 5.36 |
| CHEMBL4287345 | — | — | 1 | 5.30 |
| CHEMBL4280348 | — | — | 1 | 5.13 |
| CHEMBL4279425 | — | — | 1 | 5.00 |
| CHEMBL4276768 | — | — | 1 | 4.97 |
| CHEMBL301523 | PHENYLALANINE | 3.0 | 1 | 4.00 |
| CHEMBL1454 | LEVAMISOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4283809 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL4289564 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL4294381 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4290987 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4287165 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL4287568 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL4287104 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL4280545 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL4276925 | — | IC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL4292898 | — | IC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL4282304 | — | IC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL4287345 | — | IC50 | = | 4960.0 | nM | 5.30 |
| CHEMBL4280348 | — | IC50 | = | 7430.0 | nM | 5.13 |
| CHEMBL4279425 | — | IC50 | = | 9930.0 | nM | 5.00 |
| CHEMBL4276768 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL301523 | PHENYLALANINE | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1454 | LEVAMISOLE | IC50 | > | 200000.0 | nM | - |