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Assay Detail

CHEMBL4269458

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimicrobial activity against Mycobacterium tuberculosis H37Ra ATCC 25177 after 7 days by luminometric method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mycobacterium tuberculosis
Confidence 1 — Organism
Curated By Intermediate

Target

Mycobacterium tuberculosis (CHEMBL360)
Type ORGANISM
Organism Mycobacterium tuberculosis

Publication

Acyloxybenzyl and Alkoxyalkyl Prodrugs of a Fosmidomycin Surrogate as Antimalarial and Antitubercular Agents.
Courtens C, Risseeuw M, Caljon G, Cos P, Van Calenbergh S.
ACS Med Chem Lett (2018) 9 : 986 -989
PubMed 30344904 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.63 6.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4284446 1 6.38
CHEMBL4294662 1 6.37
CHEMBL4286765 1 6.19
CHEMBL4295103 1 5.75
CHEMBL4291253 1 4.71
CHEMBL2012484 1 4.35
CHEMBL4279252 1 -
CHEMBL4286356 1 -
CHEMBL4278442 1 -
CHEMBL4287850 1 -
CHEMBL4279944 1 -
CHEMBL4283416 1 -
CHEMBL258981 1 -
CHEMBL205338 FR-900098 1 -
CHEMBL2164257 FOSMIDOMYCIN SODIUM 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4284446 IC50 = 420.0 nM 6.38
CHEMBL4294662 IC50 = 430.0 nM 6.37
CHEMBL4286765 IC50 = 640.0 nM 6.19
CHEMBL4295103 IC50 = 1760.0 nM 5.75
CHEMBL4291253 IC50 = 19680.0 nM 4.71
CHEMBL2012484 IC50 = 44280.0 nM 4.35
CHEMBL4279252 IC50 > 64000.0 nM -
CHEMBL4286356 IC50 > 64000.0 nM -
CHEMBL4278442 IC50 > 64000.0 nM -
CHEMBL4287850 IC50 > 64000.0 nM -
CHEMBL4279944 IC50 > 64000.0 nM -
CHEMBL4283416 IC50 > 64000.0 nM -
CHEMBL258981 IC50 > 64000.0 nM -
CHEMBL205338 FR-900098 IC50 > 64000.0 nM -
CHEMBL2164257 FOSMIDOMYCIN SODIUM IC50 > 64000.0 nM -