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Assay Detail

CHEMBL4269587

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human CA4 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 4 (CHEMBL3729)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Famotidine, an Antiulcer Agent, Strongly Inhibits Helicobacter pylori and Human Carbonic Anhydrases.
Angeli A, Ferraroni M, Supuran CT.
ACS Med Chem Lett (2018) 9 : 1035 -1038
PubMed 30344913 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 6.58 7.13

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL20 ACETAZOLAMIDE 4.0 1 7.13
CHEMBL902 FAMOTIDINE 4.0 1 6.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL20 ACETAZOLAMIDE Ki = 74.0 nM 7.13
CHEMBL902 FAMOTIDINE Ki = 938.8 nM 6.03