Assay Detail
Functional
CHEMBL4269899
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Zampanolides B-E from the Marine Sponge Cacospongia mycofijiensis: Potent Cytotoxic Macrolides with Microtubule-Stabilizing Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.80 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL582439 | ZAMPANOLIDE | — | 1 | 8.49 |
| CHEMBL4287683 | — | — | 1 | 8.48 |
| CHEMBL4279451 | — | — | 1 | 8.42 |
| CHEMBL4281953 | — | — | 1 | 8.28 |
| CHEMBL4288175 | — | — | 1 | 6.62 |
| CHEMBL4289824 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL582439 | ZAMPANOLIDE | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4287683 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4279451 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4281953 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4288175 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4289824 | — | IC50 | = | 300.0 | nM | 6.52 |