Assay Detail
Functional
CHEMBL4270107
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Antibiofilm activity against Staphylococcus aureus Rosenbach ATCC 25923 after 24 hrs by crystal-violet based UV-Vis spectroscopy
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Staphylococcus aureus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.18 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285206 | — | — | 1 | 6.36 |
| CHEMBL4277733 | — | — | 1 | 6.27 |
| CHEMBL262777 | VANCOMYCIN | 4.0 | 1 | 6.27 |
| CHEMBL1632145 | — | — | 1 | 6.14 |
| CHEMBL4277902 | — | — | 1 | 6.04 |
| CHEMBL4293874 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285206 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4277733 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL262777 | VANCOMYCIN | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1632145 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4277902 | — | EC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4293874 | — | EC50 | = | 1000.0 | nM | 6.00 |