Assay Detail
Functional
CHEMBL4270108
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Bactericidal activity against Staphylococcus aureus Rosenbach ATCC 25923 in biofilms preincubated for 24 hrs followed by compound wash out and measured after 24 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Staphylococcus aureus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.47 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4277902 | — | — | 1 | 5.70 |
| CHEMBL4277733 | — | — | 1 | 5.64 |
| CHEMBL1632145 | — | — | 1 | 5.62 |
| CHEMBL4293874 | — | — | 1 | 5.25 |
| CHEMBL4285206 | — | — | 1 | 5.16 |
| CHEMBL262777 | VANCOMYCIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4277902 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4277733 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1632145 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4293874 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4285206 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL262777 | VANCOMYCIN | EC50 | > | 100000.0 | nM | - |