Assay Detail
Functional
CHEMBL4271952
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Cytotoxicity against human NCI-H1650 cells assessed as decrease in cell viability after 72 hrs by MTT assay
17
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1650 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Rational design of mitochondria-targeted pyruvate dehydrogenase kinase 1 inhibitors with improved selectivity and antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.96 | 6.68 |
| Activity | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4293270 | — | — | 2 | 6.68 |
| CHEMBL4278133 | — | — | 2 | 6.07 |
| CHEMBL4278526 | — | — | 2 | 6.06 |
| CHEMBL4286048 | — | — | 2 | 6.06 |
| CHEMBL4289177 | — | — | 2 | 6.04 |
| CHEMBL4291759 | — | — | 2 | 5.65 |
| CHEMBL3560171 | — | — | 1 | 5.17 |
| CHEMBL1970728 | — | — | 1 | - |
| CHEMBL4289887 | — | — | 1 | - |
| CHEMBL3250674 | — | — | 1 | - |
| CHEMBL4286465 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4293270 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4278133 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4278526 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4286048 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4289177 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4291759 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL3560171 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4291759 | — | Activity | - | — | - | |
| CHEMBL4286465 | — | IC50 | - | — | - | |
| CHEMBL3250674 | — | IC50 | - | — | - | |
| CHEMBL4289887 | — | IC50 | - | — | - | |
| CHEMBL1970728 | — | IC50 | - | — | - | |
| CHEMBL4293270 | — | Activity | - | — | - | |
| CHEMBL4289177 | — | Activity | - | — | - | |
| CHEMBL4286048 | — | Activity | - | — | - | |
| CHEMBL4278526 | — | Activity | - | — | - | |
| CHEMBL4278133 | — | Activity | - | — | - |