Assay Detail
Functional
CHEMBL4272593
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Antiproliferative activity against human U87 cells after 72 hrs by MTT assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Copper(I) oxide nanoparticles catalyzed click chemistry based synthesis of melampomagnolide B-triazole conjugates and their anti-cancer activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.54 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 6.80 |
| CHEMBL4290751 | — | — | 1 | 6.00 |
| CHEMBL4294165 | — | — | 1 | 5.91 |
| CHEMBL4285131 | — | — | 1 | 5.90 |
| CHEMBL4277119 | — | — | 1 | 5.90 |
| CHEMBL4284204 | — | — | 1 | 5.89 |
| CHEMBL4282880 | — | — | 1 | 5.87 |
| CHEMBL4278178 | — | — | 1 | 5.84 |
| CHEMBL4292276 | — | — | 1 | 5.83 |
| CHEMBL4280528 | — | — | 1 | 5.82 |
| CHEMBL4279410 | — | — | 1 | 5.75 |
| CHEMBL4281638 | — | — | 1 | 5.72 |
| CHEMBL4288866 | — | — | 1 | 5.72 |
| CHEMBL4289953 | — | — | 1 | 5.70 |
| CHEMBL4278041 | — | — | 1 | 5.70 |
| CHEMBL4281536 | — | — | 1 | 5.58 |
| CHEMBL4280635 | — | — | 1 | 5.55 |
| CHEMBL4279256 | — | — | 1 | 5.53 |
| CHEMBL4282461 | — | — | 1 | 5.53 |
| CHEMBL4281496 | — | — | 1 | 5.45 |
| CHEMBL4288699 | — | — | 1 | 5.43 |
| CHEMBL4294566 | — | — | 1 | 5.36 |
| CHEMBL4280439 | — | — | 1 | 5.30 |
| CHEMBL4291410 | — | — | 1 | 5.24 |
| CHEMBL4279674 | — | — | 1 | 5.21 |
| CHEMBL563939 | — | — | 1 | 5.20 |
| CHEMBL4298697 | — | — | 1 | 5.06 |
| CHEMBL4293071 | — | — | 1 | 5.03 |
| CHEMBL4280764 | — | — | 1 | 4.91 |
| CHEMBL4287584 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4290751 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4294165 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4285131 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4277119 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4284204 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4282880 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4278178 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL4292276 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL4280528 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL4279410 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4281638 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL4288866 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL4289953 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL4278041 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL4281536 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4280635 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL4279256 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL4282461 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL4281496 | — | IC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL4288699 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL4294566 | — | IC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL4280439 | — | IC50 | = | 4970.0 | nM | 5.30 |
| CHEMBL4291410 | — | IC50 | = | 5750.0 | nM | 5.24 |
| CHEMBL4279674 | — | IC50 | = | 6170.0 | nM | 5.21 |
| CHEMBL563939 | — | IC50 | = | 6280.0 | nM | 5.20 |
| CHEMBL4298697 | — | IC50 | = | 8680.0 | nM | 5.06 |
| CHEMBL4293071 | — | IC50 | = | 9310.0 | nM | 5.03 |
| CHEMBL4280764 | — | IC50 | = | 12450.0 | nM | 4.91 |
| CHEMBL4287584 | — | IC50 | = | 12990.0 | nM | 4.89 |
| CHEMBL4294821 | — | IC50 | = | 13020.0 | nM | 4.88 |
| CHEMBL4291163 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL4283971 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4283154 | — | IC50 | > | 20000.0 | nM | - |