Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4272702

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of LPS-induced PGE2 production in C57BL6 mouse peritoneal cells measured at 5 hrs time interval by ELISA
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Influence of the C-5 substitution in polysubstituted pyrimidines on inhibition of prostaglandin E2 production.
Kolman V, Kalčic F, Jansa P, Zídek Z, Janeba Z.
Eur J Med Chem (2018) 156 : 295 -301
PubMed 30006172 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.47 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL261185 1 8.52
CHEMBL6 INDOMETHACIN 4.0 1 8.30
CHEMBL4282519 1 8.05
CHEMBL4286323 1 8.05
CHEMBL4288366 1 7.48
CHEMBL4284575 1 6.92
CHEMBL4281375 1 5.73
CHEMBL4281569 1 5.67
CHEMBL4282859 1 5.63
CHEMBL4279054 1 5.61
CHEMBL4289245 1 5.55
CHEMBL4282951 1 5.47
CHEMBL4293123 1 5.43
CHEMBL25 ASPIRIN 4.0 1 5.39
CHEMBL4289663 1 5.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL261185 IC50 = 3.0 nM 8.52
CHEMBL6 INDOMETHACIN IC50 = 5.0 nM 8.30
CHEMBL4282519 IC50 = 9.0 nM 8.05
CHEMBL4286323 IC50 = 9.0 nM 8.05
CHEMBL4288366 IC50 = 33.0 nM 7.48
CHEMBL4284575 IC50 = 119.0 nM 6.92
CHEMBL4281375 IC50 = 1860.0 nM 5.73
CHEMBL4281569 IC50 = 2160.0 nM 5.67
CHEMBL4282859 IC50 = 2320.0 nM 5.63
CHEMBL4279054 IC50 = 2460.0 nM 5.61
CHEMBL4289245 IC50 = 2790.0 nM 5.55
CHEMBL4282951 IC50 = 3400.0 nM 5.47
CHEMBL4293123 IC50 = 3710.0 nM 5.43
CHEMBL25 ASPIRIN IC50 = 4080.0 nM 5.39
CHEMBL4289663 IC50 = 5340.0 nM 5.27