Assay Detail
Binding
CHEMBL4272745
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His-tagged human ARTD4 (250 to 565 residues) expressed in Escherichia coli Rosetta2 (DE3) using TCEP as substrate after 2.5 hrs in presence of NAD+
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein mono-ADP-ribosyltransferase PARP4 (CHEMBL6142) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.42 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1438938 | — | — | 1 | 4.64 |
| CHEMBL449635 | — | — | 1 | 4.19 |
| CHEMBL4287262 | — | — | 1 | - |
| CHEMBL4287655 | — | — | 1 | - |
| CHEMBL4208737 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1438938 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL449635 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL4287262 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4287655 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4208737 | — | IC50 | > | 100000.0 | nM | - |