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Assay Detail

CHEMBL4273052

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant carbonic anhydrase 7 assessed as CO2 hydration preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red dye-based stopped-flow assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 7 (CHEMBL2326)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal.
Mishra CB, Kumari S, Angeli A, Bua S, Buonanno M, Monti SM, Tiwari M, Supuran CT.
Eur J Med Chem (2018) 156 : 430 -443
PubMed 30015076 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 7.12 8.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL20 ACETAZOLAMIDE 4.0 1 8.60
CHEMBL4280796 1 8.21
CHEMBL4279656 1 7.94
CHEMBL4292534 1 7.75
CHEMBL4285604 1 7.38
CHEMBL4280099 1 7.30
CHEMBL4288399 1 7.14
CHEMBL4293582 1 7.10
CHEMBL4285726 1 7.02
CHEMBL4287995 1 7.01
CHEMBL4277762 1 6.93
CHEMBL4285351 1 6.92
CHEMBL4281925 1 6.90
CHEMBL4290322 1 6.89
CHEMBL4277397 1 6.88
CHEMBL4281197 1 6.87
CHEMBL4284225 1 6.83
CHEMBL4292113 1 6.83
CHEMBL4288695 1 6.74
CHEMBL4291819 1 6.22
CHEMBL4277666 1 6.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL20 ACETAZOLAMIDE Ki = 2.5 nM 8.60
CHEMBL4280796 Ki = 6.2 nM 8.21
CHEMBL4279656 Ki = 11.4 nM 7.94
CHEMBL4292534 Ki = 17.8 nM 7.75
CHEMBL4285604 Ki = 41.5 nM 7.38
CHEMBL4280099 Ki = 49.6 nM 7.30
CHEMBL4288399 Ki = 72.0 nM 7.14
CHEMBL4293582 Ki = 78.8 nM 7.10
CHEMBL4285726 Ki = 94.7 nM 7.02
CHEMBL4287995 Ki = 98.4 nM 7.01
CHEMBL4277762 Ki = 118.2 nM 6.93
CHEMBL4285351 Ki = 121.5 nM 6.92
CHEMBL4281925 Ki = 125.9 nM 6.90
CHEMBL4290322 Ki = 127.4 nM 6.89
CHEMBL4277397 Ki = 132.2 nM 6.88
CHEMBL4281197 Ki = 135.3 nM 6.87
CHEMBL4284225 Ki = 147.1 nM 6.83
CHEMBL4292113 Ki = 147.7 nM 6.83
CHEMBL4288695 Ki = 180.8 nM 6.74
CHEMBL4291819 Ki = 606.7 nM 6.22
CHEMBL4277666 Ki = 750.9 nM 6.12