Assay Detail
Binding
CHEMBL4273242
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Inhibition of human serum BuChE using butyrylthiocholine as substrate pretreated for 5 mins followed by substrate addition and measured for 5 mins by Ellman's method
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.20 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.60 |
| CHEMBL4292477 | — | — | 1 | 5.37 |
| CHEMBL4286799 | — | — | 1 | 5.29 |
| CHEMBL4291372 | — | — | 1 | 5.24 |
| CHEMBL4284591 | — | — | 1 | 5.20 |
| CHEMBL4283450 | — | — | 1 | 5.19 |
| CHEMBL4289318 | — | — | 1 | 5.06 |
| CHEMBL4277548 | — | — | 1 | 5.03 |
| CHEMBL4294609 | — | — | 1 | 5.00 |
| CHEMBL4285779 | — | — | 1 | 5.00 |
| CHEMBL4294701 | — | — | 1 | - |
| CHEMBL4285912 | — | — | 1 | - |
| CHEMBL4287548 | — | — | 1 | - |
| CHEMBL4290401 | — | — | 1 | - |
| CHEMBL4282527 | — | — | 1 | - |
| CHEMBL4277332 | — | — | 1 | - |
| CHEMBL4287970 | — | — | 1 | - |
| CHEMBL4280725 | — | — | 1 | - |
| CHEMBL4284165 | — | — | 1 | - |
| CHEMBL4294783 | — | — | 1 | - |
| CHEMBL4293801 | — | — | 1 | - |
| CHEMBL4284495 | — | — | 1 | - |
| CHEMBL4295144 | — | — | 1 | - |
| CHEMBL4287889 | — | — | 1 | - |
| CHEMBL4285601 | — | — | 1 | - |
| CHEMBL4286731 | — | — | 1 | - |
| CHEMBL4292446 | — | — | 1 | - |
| CHEMBL4283079 | — | — | 1 | - |
| CHEMBL4290940 | — | — | 1 | - |
| CHEMBL4291296 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4292477 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4286799 | — | IC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL4291372 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4284591 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4283450 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4289318 | — | IC50 | = | 8790.0 | nM | 5.06 |
| CHEMBL4277548 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4294609 | — | IC50 | = | 9880.0 | nM | 5.00 |
| CHEMBL4285779 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4294701 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4285912 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4287548 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4290401 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4282527 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4277332 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4287970 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4280725 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4284165 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4294783 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4293801 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4284495 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4295144 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4287889 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4285601 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4286731 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4292446 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4283079 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4290940 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4291296 | — | IC50 | > | 10000.0 | nM | - |