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Assay Detail

CHEMBL4273352

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ADMET
Inhibition of AChE (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL220)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities.
Knez D, Coquelle N, Pišlar A, Žakelj S, Jukič M, Sova M, Mravljak J, Nachon F, Brazzolotto X, Kos J, Colletier JP, Gobec S.
Eur J Med Chem (2018) 156 : 598 -617
PubMed 30031971 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 6.57 7.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL502 DONEPEZIL 4.0 1 7.66
CHEMBL659 GALANTAMINE 4.0 1 6.52
CHEMBL636 RIVASTIGMINE 4.0 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL502 DONEPEZIL IC50 = 22.0 nM 7.66
CHEMBL659 GALANTAMINE IC50 = 300.0 nM 6.52
CHEMBL636 RIVASTIGMINE IC50 = 3030.0 nM 5.52