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Assay Detail

CHEMBL4273353

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of BChE (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cholinesterase (CHEMBL1914)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities.
Knez D, Coquelle N, Pišlar A, Žakelj S, Jukič M, Sova M, Mravljak J, Nachon F, Brazzolotto X, Kos J, Colletier JP, Gobec S.
Eur J Med Chem (2018) 156 : 598 -617
PubMed 30031971 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 6.02 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL636 RIVASTIGMINE 4.0 1 7.52
CHEMBL502 DONEPEZIL 4.0 1 5.38
CHEMBL659 GALANTAMINE 4.0 1 5.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL636 RIVASTIGMINE IC50 = 30.0 nM 7.52
CHEMBL502 DONEPEZIL IC50 = 4150.0 nM 5.38
CHEMBL659 GALANTAMINE IC50 = 7000.0 nM 5.16