Assay Detail
Functional
CHEMBL4274074
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against wild type bloodstream form of Trypanosoma brucei brucei S427 after 72 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.40 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4288624 | — | — | 1 | 7.05 |
| CHEMBL4280330 | — | — | 1 | 6.41 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4288624 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4280330 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 1870.0 | nM | 5.73 |