Assay Detail
Functional
CHEMBL4274196
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Cytotoxicity against human HCT116 cells after 24 hrs by SRB assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, antiproliferative activity, molecular docking and cell cycle analysis of some novel (morpholinosulfonyl) isatins with potential EGFR inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.77 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 5.23 |
| CHEMBL4289728 | — | — | 1 | 5.17 |
| CHEMBL4280749 | — | — | 1 | 5.13 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.08 |
| CHEMBL4284841 | — | — | 1 | 5.01 |
| CHEMBL4282506 | — | — | 1 | 4.99 |
| CHEMBL4281426 | — | — | 1 | 4.98 |
| CHEMBL4289297 | — | — | 1 | 4.88 |
| CHEMBL4292064 | — | — | 1 | 4.82 |
| CHEMBL4276927 | — | — | 1 | 4.80 |
| CHEMBL4289083 | — | — | 1 | 4.74 |
| CHEMBL4277353 | — | — | 1 | 4.73 |
| CHEMBL4278412 | — | — | 1 | 4.72 |
| CHEMBL4284186 | — | — | 1 | 4.72 |
| CHEMBL4277968 | — | — | 1 | 4.63 |
| CHEMBL4285307 | — | — | 1 | 4.63 |
| CHEMBL4280602 | — | — | 1 | 4.61 |
| CHEMBL4288648 | — | — | 1 | 4.56 |
| CHEMBL4287569 | — | — | 1 | 4.54 |
| CHEMBL4285893 | — | — | 1 | 4.54 |
| CHEMBL4293110 | — | — | 1 | 4.54 |
| CHEMBL4292712 | — | — | 1 | 4.44 |
| CHEMBL484273 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554 | LAPATINIB | IC50 | = | 5920.0 | nM | 5.23 |
| CHEMBL4289728 | — | IC50 | = | 6750.0 | nM | 5.17 |
| CHEMBL4280749 | — | IC50 | = | 7480.0 | nM | 5.13 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 8290.0 | nM | 5.08 |
| CHEMBL4284841 | — | IC50 | = | 9730.0 | nM | 5.01 |
| CHEMBL4282506 | — | IC50 | = | 10270.0 | nM | 4.99 |
| CHEMBL4281426 | — | IC50 | = | 10490.0 | nM | 4.98 |
| CHEMBL4289297 | — | IC50 | = | 13260.0 | nM | 4.88 |
| CHEMBL4292064 | — | IC50 | = | 15290.0 | nM | 4.82 |
| CHEMBL4276927 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL4289083 | — | IC50 | = | 18050.0 | nM | 4.74 |
| CHEMBL4277353 | — | IC50 | = | 18650.0 | nM | 4.73 |
| CHEMBL4278412 | — | IC50 | = | 19160.0 | nM | 4.72 |
| CHEMBL4284186 | — | IC50 | = | 18860.0 | nM | 4.72 |
| CHEMBL4277968 | — | IC50 | = | 23430.0 | nM | 4.63 |
| CHEMBL4285307 | — | IC50 | = | 23570.0 | nM | 4.63 |
| CHEMBL4280602 | — | IC50 | = | 24310.0 | nM | 4.61 |
| CHEMBL4288648 | — | IC50 | = | 27340.0 | nM | 4.56 |
| CHEMBL4287569 | — | IC50 | = | 29010.0 | nM | 4.54 |
| CHEMBL4285893 | — | IC50 | = | 29010.0 | nM | 4.54 |
| CHEMBL4293110 | — | IC50 | = | 28910.0 | nM | 4.54 |
| CHEMBL4292712 | — | IC50 | = | 36290.0 | nM | 4.44 |
| CHEMBL484273 | — | IC50 | = | 59970.0 | nM | 4.22 |