Assay Detail
Binding
CHEMBL4274263
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Inhibition of human erythrocyte AChE using acetylthiocholine chloride as substrate incubated for 5 mins followed by substrate addition measured after 180 secs by Ellman's method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.80 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.32 |
| CHEMBL3819548 | — | — | 1 | 6.35 |
| CHEMBL4292766 | — | — | 1 | 6.12 |
| CHEMBL4284475 | — | — | 1 | 6.01 |
| CHEMBL4295126 | — | — | 1 | 5.88 |
| CHEMBL4279488 | — | — | 1 | 5.86 |
| CHEMBL4281066 | — | — | 1 | 5.79 |
| CHEMBL4291697 | — | — | 1 | 5.75 |
| CHEMBL4284895 | — | — | 1 | 5.70 |
| CHEMBL4288282 | — | — | 1 | 5.67 |
| CHEMBL4283390 | — | — | 1 | 5.65 |
| CHEMBL4286736 | — | — | 1 | 5.61 |
| CHEMBL4293155 | — | — | 1 | 5.61 |
| CHEMBL4277644 | — | — | 1 | 5.60 |
| CHEMBL3819320 | — | — | 1 | 5.60 |
| CHEMBL4282558 | — | — | 1 | 5.59 |
| CHEMBL4278260 | — | — | 1 | 5.56 |
| CHEMBL4287826 | — | — | 1 | 5.47 |
| CHEMBL4292349 | — | — | 1 | 5.46 |
| CHEMBL4281727 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3819548 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4292766 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4284475 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4295126 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL4279488 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL4281066 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL4291697 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL4284895 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL4288282 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL4283390 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL4286736 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL4293155 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL4277644 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL3819320 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL4282558 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL4278260 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL4287826 | — | IC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL4292349 | — | IC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL4281727 | — | IC50 | = | 3810.0 | nM | 5.42 |