Assay Detail
Binding
CHEMBL4274267
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate incubated for 5 mins followed by substrate addition measured after 180 secs by Ellman's method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.17 | 5.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3819320 | — | — | 1 | 5.91 |
| CHEMBL3819548 | — | — | 1 | 5.78 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.50 |
| CHEMBL4286736 | — | — | 1 | 5.02 |
| CHEMBL4279488 | — | — | 1 | 4.71 |
| CHEMBL4283390 | — | — | 1 | 4.07 |
| CHEMBL4288282 | — | — | 1 | - |
| CHEMBL4284895 | — | — | 1 | - |
| CHEMBL4295126 | — | — | 1 | - |
| CHEMBL4284475 | — | — | 1 | - |
| CHEMBL4291697 | — | — | 1 | - |
| CHEMBL4281066 | — | — | 1 | - |
| CHEMBL4293155 | — | — | 1 | - |
| CHEMBL4282558 | — | — | 1 | - |
| CHEMBL4281727 | — | — | 1 | - |
| CHEMBL4292349 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3819320 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL3819548 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL4286736 | — | IC50 | = | 9610.0 | nM | 5.02 |
| CHEMBL4279488 | — | IC50 | = | 19560.0 | nM | 4.71 |
| CHEMBL4283390 | — | IC50 | = | 84810.0 | nM | 4.07 |
| CHEMBL4288282 | — | IC50 | - | — | - | |
| CHEMBL4284895 | — | IC50 | - | — | - | |
| CHEMBL4295126 | — | IC50 | - | — | - | |
| CHEMBL4284475 | — | IC50 | - | — | - | |
| CHEMBL4291697 | — | IC50 | - | — | - | |
| CHEMBL4281066 | — | IC50 | - | — | - | |
| CHEMBL4293155 | — | IC50 | - | — | - | |
| CHEMBL4282558 | — | IC50 | - | — | - | |
| CHEMBL4281727 | — | IC50 | - | — | - | |
| CHEMBL4292349 | — | IC50 | - | — | - |