Assay Detail
Functional
CHEMBL4274356
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Antiproliferative activity against human HeLa cells after 72 hrs by Coulter counter method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of a 3'-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.18 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4276891 | — | — | 1 | 7.29 |
| CHEMBL4287532 | — | — | 1 | 7.03 |
| CHEMBL4277322 | — | — | 1 | 6.82 |
| CHEMBL4295176 | — | — | 1 | 6.75 |
| CHEMBL4281756 | — | — | 1 | 6.75 |
| CHEMBL2094094 | — | — | 1 | 6.54 |
| CHEMBL4281102 | — | — | 1 | 6.12 |
| CHEMBL4284518 | — | — | 1 | 6.06 |
| CHEMBL4281512 | — | — | 1 | 6.05 |
| CHEMBL4289398 | — | — | 1 | 5.96 |
| CHEMBL4288972 | — | — | 1 | 5.77 |
| CHEMBL4284939 | — | — | 1 | 5.36 |
| CHEMBL4292803 | — | — | 1 | 5.20 |
| CHEMBL4291736 | — | — | 1 | 4.85 |
| CHEMBL4288324 | — | — | 1 | - |
| CHEMBL4277684 | — | — | 1 | - |
| CHEMBL4278293 | — | — | 1 | - |
| CHEMBL4285278 | — | — | 1 | - |
| CHEMBL4280712 | — | — | 1 | - |
| CHEMBL4288621 | — | — | 1 | - |
| CHEMBL4289054 | — | — | 1 | - |
| CHEMBL4278380 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4276891 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4287532 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4277322 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4295176 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4281756 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2094094 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4281102 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4284518 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4281512 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4289398 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4288972 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4284939 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4292803 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4291736 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4288324 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4277684 | — | IC50 | = | 114000.0 | nM | - |
| CHEMBL4278293 | — | IC50 | = | 135000.0 | nM | - |
| CHEMBL4285278 | — | IC50 | = | 220000.0 | nM | - |
| CHEMBL4280712 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL4288621 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4289054 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL4278380 | — | IC50 | > | 250000.0 | nM | - |