Assay Detail
Functional
CHEMBL4274764
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Antiproliferative activity against human HT1080 cells after 72 hrs by sulforhodamine-B assay
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.88 | 5.70 |
| Activity | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4287905 | — | — | 2 | 5.70 |
| CHEMBL4283244 | — | — | 2 | 4.70 |
| CHEMBL2031263 | — | — | 2 | 4.57 |
| CHEMBL4293834 | — | — | 2 | 4.54 |
| CHEMBL473417 | VISMODEGIB | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4287905 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4283244 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2031263 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4293834 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL473417 | VISMODEGIB | IC50 | > | 100000.0 | nM | - |
| CHEMBL473417 | VISMODEGIB | Activity | - | — | - | |
| CHEMBL4283244 | — | Activity | - | — | - | |
| CHEMBL4293834 | — | Activity | - | — | - | |
| CHEMBL4287905 | — | Activity | - | — | - | |
| CHEMBL2031263 | — | Activity | - | — | - |