Assay Detail
Binding
CHEMBL4275246
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Inhibition of recombinant human C-terminal His-tagged MAGL expressed in Escherichia coli using 4-NPA as substrate measured after 30 mins
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 5.25 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL570812 | — | — | 1 | 6.85 |
| CHEMBL4293423 | — | — | 1 | 6.17 |
| CHEMBL4284088 | — | — | 1 | 6.15 |
| CHEMBL4282758 | — | — | 1 | 6.11 |
| CHEMBL4282040 | — | — | 1 | 6.08 |
| CHEMBL4283120 | — | — | 1 | 6.04 |
| CHEMBL4293367 | — | — | 1 | 6.02 |
| CHEMBL4291956 | — | — | 1 | 6.00 |
| CHEMBL4289986 | — | — | 1 | 5.96 |
| CHEMBL4285844 | — | — | 1 | 5.89 |
| CHEMBL4279301 | — | — | 1 | 5.82 |
| CHEMBL4280805 | — | — | 1 | 5.77 |
| CHEMBL4279032 | — | — | 1 | 5.77 |
| CHEMBL4277602 | — | — | 1 | 5.70 |
| CHEMBL4283165 | — | — | 1 | 5.62 |
| CHEMBL4286559 | — | — | 1 | 5.60 |
| CHEMBL4291020 | — | — | 1 | 5.48 |
| CHEMBL4278225 | — | — | 1 | 5.32 |
| CHEMBL4284990 | — | — | 1 | 5.29 |
| CHEMBL4294450 | — | — | 1 | 5.28 |
| CHEMBL4286138 | — | — | 1 | 5.14 |
| CHEMBL3409959 | — | — | 1 | 4.96 |
| CHEMBL4292707 | — | — | 1 | 4.92 |
| CHEMBL4294185 | — | — | 1 | 4.80 |
| CHEMBL4287594 | — | — | 1 | 4.75 |
| CHEMBL4284676 | — | — | 1 | 4.72 |
| CHEMBL4284214 | — | — | 1 | 4.70 |
| CHEMBL4279686 | — | — | 1 | 4.60 |
| CHEMBL4284837 | — | — | 1 | 4.58 |
| CHEMBL4291427 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL570812 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4293423 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4284088 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL4282758 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4282040 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4283120 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4293367 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4291956 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4289986 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4285844 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4279301 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4280805 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4279032 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4277602 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4283165 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4286559 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4291020 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4278225 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4284990 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4294450 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4286138 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3409959 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4292707 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4294185 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4287594 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4284676 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4284214 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4279686 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4284837 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4291427 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4281690 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3409958 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4294836 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4286305 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4288022 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4294988 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL4277378 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL4280782 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL4293107 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4293042 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4289567 | — | IC50 | = | 119000.0 | nM | - |