Assay Detail
Binding
CHEMBL4275676
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of R1881-induced transcriptional activity of human AR V7 truncated mutant expressed in human PC3 cells harboring pGL3-ARR3tk-NLuc after 24 hrs by luciferase reporter gene assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Small molecule-induced degradation of the full length and V7 truncated variant forms of human androgen receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.00 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1210876 | — | — | 1 | 5.00 |
| CHEMBL1210959 | — | — | 1 | 5.00 |
| CHEMBL1210878 | — | — | 1 | 5.00 |
| CHEMBL1210880 | — | — | 1 | - |
| CHEMBL113332 | — | — | 1 | - |
| CHEMBL4278637 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1210876 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1210959 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1210878 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1210880 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL113332 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4278637 | — | IC50 | < | 10000.0 | nM | - |