Assay Detail
Binding
CHEMBL4275701
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Displacement of fluormone VDR red from human full-length VDR after 4 hrs by fluorescence polarization assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Sulfonyl-containing phenyl-pyrrolyl pentane analogues: Novel non-secosteroidal vitamin D receptor modulators with favorable physicochemical properties, pharmacokinetic properties and anti-tumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.44 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 8.85 |
| CHEMBL4288947 | — | — | 1 | 7.05 |
| CHEMBL2434990 | — | — | 1 | 6.94 |
| CHEMBL4290851 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL846 | CALCITRIOL | IC50 | = | 1.42 | nM | 8.85 |
| CHEMBL4288947 | — | IC50 | = | 89.1 | nM | 7.05 |
| CHEMBL2434990 | — | IC50 | = | 115.3 | nM | 6.94 |
| CHEMBL4290851 | — | IC50 | = | 125.4 | nM | 6.90 |