Assay Detail
Functional
CHEMBL4275887
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Antiproliferative activity against human HEMC-SS cells treated for 24 hrs under hypoxic condition followed by compound wash-out and incubated under normoxic condition for 48 hrs by alamar blue assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H-EMC-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationship study of hypoxia-activated prodrugs for proteoglycan-targeted chemotherapy in chondrosarcoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.87 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260046 | EVOFOSFAMIDE | 3.0 | 1 | 6.89 |
| CHEMBL4294007 | — | — | 1 | 6.40 |
| CHEMBL4278857 | — | — | 1 | 6.10 |
| CHEMBL4289535 | — | — | 1 | 5.96 |
| CHEMBL4282724 | — | — | 1 | 5.85 |
| CHEMBL4283062 | — | — | 1 | 5.82 |
| CHEMBL4279260 | — | — | 1 | 5.82 |
| CHEMBL4284207 | — | — | 1 | 5.77 |
| CHEMBL4286107 | — | — | 1 | 5.75 |
| CHEMBL4292087 | — | — | 1 | 5.68 |
| CHEMBL4290926 | — | — | 1 | 5.62 |
| CHEMBL4287185 | — | — | 1 | 5.62 |
| CHEMBL4290602 | — | — | 1 | 5.55 |
| CHEMBL4277694 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260046 | EVOFOSFAMIDE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4294007 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4278857 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4289535 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4282724 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4283062 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4279260 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4284207 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4286107 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4292087 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4290926 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4287185 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4290602 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4277694 | — | IC50 | = | 4300.0 | nM | 5.37 |