Assay Detail
Binding
CHEMBL4276022
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of beta-glucosidase derived from human peripheral blood mononuclear cell lysate using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 2 hrs by fluorescence analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
4-epi-Isofagomine derivatives as pharmacological chaperones for the treatment of lysosomal diseases linked to β-galactosidase mutations: Improved synthesis and biological investigations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.28 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL206468 | AFEGOSTAT | 2.0 | 1 | 7.70 |
| CHEMBL4288931 | — | — | 1 | 7.40 |
| CHEMBL4085739 | — | — | 1 | 5.00 |
| CHEMBL4284436 | — | — | 1 | 5.00 |
| CHEMBL4281031 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL206468 | AFEGOSTAT | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4288931 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4085739 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4284436 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4281031 | — | IC50 | > | 10000.0 | nM | - |