Assay Detail
Functional
CHEMBL4276409
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Atazanavir-resistant HIV1 infected in human MT4 cells assessed as reduction in p24 Gag protein production after 7 days by automated chemiluminescent enzyme immunoassay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and Synthesis of Potent HIV-1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure-Activity Studies and Biological and X-ray Structural Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.29 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 7.72 |
| CHEMBL4277539 | — | — | 1 | 7.48 |
| CHEMBL4292006 | — | — | 1 | 7.44 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 6.51 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | - |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4277539 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4292006 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL729 | LOPINAVIR | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL116 | AMPRENAVIR | IC50 | > | 1000.0 | nM | - |
| CHEMBL1163 | ATAZANAVIR | IC50 | > | 1000.0 | nM | - |