Assay Detail
Binding
CHEMBL4276427
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant N-terminal His6-tagged P110alpha catalytic domain (unknown origin) after 1 hr by TR-FRET displacement assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 6.55 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4280087 | — | — | 1 | 7.94 |
| CHEMBL4284651 | — | — | 1 | 7.75 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 7.70 |
| CHEMBL4287799 | — | — | 1 | 7.68 |
| CHEMBL4279881 | — | — | 1 | 7.62 |
| CHEMBL4279445 | — | — | 1 | 7.59 |
| CHEMBL4288037 | — | — | 1 | 7.54 |
| CHEMBL4281768 | — | — | 1 | 7.49 |
| CHEMBL4277399 | — | — | 1 | 7.39 |
| CHEMBL4285600 | — | — | 1 | 7.19 |
| CHEMBL4282438 | — | — | 1 | 7.16 |
| CHEMBL4290312 | — | — | 1 | 7.09 |
| CHEMBL4291199 | — | — | 1 | 6.89 |
| CHEMBL4277247 | — | — | 1 | 6.85 |
| CHEMBL4278312 | — | — | 1 | 6.20 |
| CHEMBL4290128 | — | — | 1 | 6.20 |
| CHEMBL4283349 | — | — | 1 | 6.16 |
| CHEMBL4294600 | — | — | 1 | 5.89 |
| CHEMBL4277797 | — | — | 1 | 5.68 |
| CHEMBL4285727 | — | — | 1 | 5.66 |
| CHEMBL4281245 | — | — | 1 | 5.65 |
| CHEMBL4278707 | — | — | 1 | 5.62 |
| CHEMBL4286698 | — | — | 1 | 5.38 |
| CHEMBL4288210 | — | — | 1 | 5.33 |
| CHEMBL4289122 | — | — | 1 | 5.25 |
| CHEMBL4288989 | — | — | 1 | 5.06 |
| CHEMBL4293439 | — | — | 1 | 4.81 |
| CHEMBL4286621 | — | — | 1 | - |
| CHEMBL4277562 | — | — | 1 | - |
| CHEMBL4285202 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4280087 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL4284651 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL2017974 | BUPARLISIB | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL4287799 | — | Ki | = | 20.8 | nM | 7.68 |
| CHEMBL4279881 | — | Ki | = | 23.7 | nM | 7.62 |
| CHEMBL4279445 | — | Ki | = | 25.8 | nM | 7.59 |
| CHEMBL4288037 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL4281768 | — | Ki | = | 32.2 | nM | 7.49 |
| CHEMBL4277399 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL4285600 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL4282438 | — | Ki | = | 68.6 | nM | 7.16 |
| CHEMBL4290312 | — | Ki | = | 81.3 | nM | 7.09 |
| CHEMBL4291199 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL4277247 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL4278312 | — | Ki | = | 632.0 | nM | 6.20 |
| CHEMBL4290128 | — | Ki | = | 633.0 | nM | 6.20 |
| CHEMBL4283349 | — | Ki | = | 693.0 | nM | 6.16 |
| CHEMBL4294600 | — | Ki | = | 1297.0 | nM | 5.89 |
| CHEMBL4277797 | — | Ki | = | 2090.0 | nM | 5.68 |
| CHEMBL4285727 | — | Ki | = | 2190.0 | nM | 5.66 |
| CHEMBL4281245 | — | Ki | = | 2230.0 | nM | 5.65 |
| CHEMBL4278707 | — | Ki | = | 2379.0 | nM | 5.62 |
| CHEMBL4286698 | — | Ki | = | 4203.0 | nM | 5.38 |
| CHEMBL4288210 | — | Ki | = | 4632.0 | nM | 5.33 |
| CHEMBL4289122 | — | Ki | = | 5668.0 | nM | 5.25 |
| CHEMBL4288989 | — | Ki | = | 8787.0 | nM | 5.06 |
| CHEMBL4293439 | — | Ki | = | 15364.0 | nM | 4.81 |
| CHEMBL4286621 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL4277562 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL4285202 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL4292392 | — | Ki | > | 20000.0 | nM | - |